CSGALNACT1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IP, IHC-P, E |
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Primary Accession | Q8TDX6 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 61 KDa |
Gene ID | 55790 |
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Other Names | Chondroitin sulfate N-acetylgalactosaminyltransferase 1, CsGalNAcT-1, Chondroitin beta-1, 4-N-acetylgalactosaminyltransferase 1, Beta4GalNAcT-1, CSGALNACT1, CHGN, GALNACT1 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | CSGALNACT1 (HGNC:24290) |
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Synonyms | CHGN, GALNACT1 |
Function | Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758, PubMed:31705726). Moreover, is involved in the metabolism of aggrecan (By similarity). |
Cellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein |
Tissue Location | Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage.
References
Uyama T.,et al.J. Biol. Chem. 277:8841-8846(2002).
Gotoh M.,et al.J. Biol. Chem. 277:38189-38196(2002).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
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