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Cytochrome P450 2A13 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP, ICC, IHC-P, E |
|---|---|
| Primary Accession | Q16696 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 57 KDa |
| Gene ID | 1553 |
|---|---|
| Other Names | Cytochrome P450 2A13, CYPIIA13, CYP2A13 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cytochrome P450 2A13. The exact sequence is proprietary. |
| Dilution | WB~~1:1000 IP~~N/A ICC~~N/A IHC-P~~N/A E~~N/A |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CYP2A13 |
|---|---|
| Function | Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco- specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. |
| Cellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein |
| Tissue Location | Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N- dimethylaniline, 2'-methoxyacetophenone, N- nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.
References
Fernandez-Salguero P.,et al.Am. J. Hum. Genet. 57:651-660(1995).
Su T.,et al.Cancer Res. 60:5074-5079(2000).
Cauffiez C.,et al.Biochem. Biophys. Res. Commun. 317:662-669(2004).
DeVore N.M.,et al.Drug Metab. Dispos. 36:2582-2590(2008).
Sansen S.,et al.Arch. Biochem. Biophys. 464:197-206(2007).
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