Cytochrome P450 4X1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q8N118 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 59 KDa |
Antigen Region | 231 - 290 aa |
Gene ID | 260293 |
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Other Names | Cytochrome P450 4X1, CYPIVX1, CYP4X1 |
Target/Specificity | KLH conjugated synthetic peptide derived from human Cytochrome P450 4X1 |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | CYP4X1 {ECO:0000303|PubMed:18549450, ECO:0000312|HGNC:HGNC:20244} |
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Function | A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). |
Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6A152}; Single-pass membrane protein. Microsome membrane {ECO:0000250|UniProtKB:Q6A152}; Single-pass membrane protein |
Tissue Location | Expressed in brain, heart, kidney and skin and, at lower levels, in skeletal muscle and liver (PubMed:16478468, PubMed:18549450). In the brain, high levels are detected in amygdala and lower levels in globus pallidus and cerebellum (PubMed:18549450) In the heart, very high levels in aorta, but very low levels in other heart regions (PubMed:16478468, PubMed:18549450). Also expressed in breast, prostate and colon (PubMed:18549450) |
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Provided below are standard protocols that you may find useful for product applications.
References
Al-Anizy M.,et al.FEBS J. 273:936-947(2006).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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