FRK Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | P42685 |
Reactivity | Human, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 54 KDa |
Antigen Region | 81 - 140 aa |
Gene ID | 2444 |
---|---|
Other Names | Tyrosine-protein kinase FRK, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, FRK, PTK5, RAK |
Target/Specificity | KLH conjugated synthetic peptide derived from human FRK |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | FRK |
---|---|
Synonyms | PTK5, RAK |
Function | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. |
Cellular Location | Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery |
Tissue Location | Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon |
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Provided below are standard protocols that you may find useful for product applications.
Background
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
References
Cance W.G.,et al.Cell Growth Differ. 5:1347-1355(1994).
Lee J.,et al.Gene 138:247-251(1994).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Cance W.G.,et al.Int. J. Cancer 54:571-577(1993).
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