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MEOX2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MEOX2 Antibody AP51341
    All lanes : Anti-MEOX2 Antibody at 1:1000 dilution Lane 1: Hela whole cell lysates Lane 2: NIH/3T3 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 34 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P50222
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 34 KDa
Antigen Region 161 - 220 aa
Additional Information
Gene ID 4223
Other Names Homeobox protein MOX-2, Growth arrest-specific homeobox, Mesenchyme homeobox 2, MEOX2, GAX, MOX2
Target/Specificity KLH conjugated synthetic peptide derived from human MEOX2
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name MEOX2 {ECO:0000303|PubMed:16335786, ECO:0000312|HGNC:HGNC:7014}
Function Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000). While it activates CDKN1A in a DNA- dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity).
Cellular Location Nucleus. Nucleus speckle
Research Areas
Citations (0)
citation

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Background

Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity).

References

Grigoriou M.,et al.Genomics 26:550-555(1995).
Lepage D.F.,et al.Genomics 24:535-540(1994).
Hillier L.W.,et al.Nature 424:157-164(2003).
Lin J.,et al.Mol. Cell. Biochem. 275:75-84(2005).
Salichs E.,et al.PLoS Genet. 5:E1000397-E1000397(2009).

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$ 350.00
Cat# AP51341
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