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MEOX2 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P50222 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34 KDa |
| Antigen Region | 161 - 220 aa |
| Gene ID | 4223 |
|---|---|
| Other Names | Homeobox protein MOX-2, Growth arrest-specific homeobox, Mesenchyme homeobox 2, MEOX2, GAX, MOX2 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MEOX2. The exact sequence is proprietary. |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | MEOX2 {ECO:0000303|PubMed:16335786, ECO:0000312|HGNC:HGNC:7014} |
|---|---|
| Function | Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000). While it activates CDKN1A in a DNA- dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity). |
| Cellular Location | Nucleus. Nucleus speckle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity).
References
Grigoriou M.,et al.Genomics 26:550-555(1995).
Lepage D.F.,et al.Genomics 24:535-540(1994).
Hillier L.W.,et al.Nature 424:157-164(2003).
Lin J.,et al.Mol. Cell. Biochem. 275:75-84(2005).
Salichs E.,et al.PLoS Genet. 5:E1000397-E1000397(2009).
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