RIT1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q92963 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 25 KDa |
Antigen Region | 151 - 210 aa |
Gene ID | 6016 |
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Other Names | GTP-binding protein Rit1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1, RIT1, RIBB, RIT, ROC1 |
Target/Specificity | KLH conjugated synthetic peptide derived from human RIT1 |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | RIT1 |
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Synonyms | RIBB, RIT, ROC1 |
Function | Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. |
Cellular Location | Cell membrane. |
Tissue Location | Expressed in many tissues. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.
References
Lee C.H.J.,et al.J. Neurosci. 16:6784-6794(1996).
Wes P.D.,et al.EMBO J. 15:5839-5848(1996).
Kawasaki H.,et al.Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
Shao H.,et al.Arch. Biochem. Biophys. 371:207-219(1999).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
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