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SLC6A17 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H1V8 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 81 KDa |
| Gene ID | 388662 |
|---|---|
| Other Names | Sodium-dependent neutral amino acid transporter SLC6A17, Sodium-dependent neurotransmitter transporter NTT4, Solute carrier family 6 member 17, SLC6A17, NTT4 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SLC6A17 {ECO:0000250|UniProtKB:P31662, ECO:0000312|HGNC:HGNC:31399} |
|---|---|
| Function | Synaptic vesicle transporter with apparent selectivity for neutral amino acids. The transport is sodium-coupled but chloride- independent, likely driven by the proton electrochemical gradient generated by vacuolar H(+)-ATPase in an overall electrogenic mechanism. May contribute to the synaptic uptake of neurotransmitter precursors in a process coupled in part to vesicle exocytosis. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P31662}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31662}. Postsynapse {ECO:0000250|UniProtKB:Q8BJI1}. Presynapse {ECO:0000250|UniProtKB:Q8BJI1}. Note=Localizes at synaptic junctions - at both pre- and post-synaptic sites - particularly in excitatory glutamatergic terminals. {ECO:0000250|UniProtKB:Q8BJI1} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Hoglund P.J.,et al.Biochem. Biophys. Res. Commun. 336:175-189(2005).
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