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TIN2 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9BSI4 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 40 KDa |
| Gene ID | 26277 |
|---|---|
| Other Names | TERF1-interacting nuclear factor 2, TRF1-interacting nuclear protein 2, TINF2, TIN2 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | TINF2 |
|---|---|
| Synonyms | TIN2 |
| Function | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. |
| Cellular Location | Nucleus. Chromosome, telomere. Note=Associated with telomeres |
| Tissue Location | Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
References
Kim S.-H.,et al.Nat. Genet. 23:405-412(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Loayza D.,et al.Nature 423:1013-1018(2003).
Ye J.Z.-S.,et al.Genes Dev. 18:1649-1654(2004).
Ye J.Z.-S.,et al.J. Biol. Chem. 279:47264-47271(2004).
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