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TSC22 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC, IHC-P, E |
|---|---|
| Primary Accession | Q15714 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 16 KDa |
| Gene ID | 8848 |
|---|---|
| Other Names | TSC22 domain family protein 1, Cerebral protein 2, Regulatory protein TSC-22, TGFB-stimulated clone 22 homolog, Transforming growth factor beta-1-induced transcript 4 protein, TSC22D1, KIAA1994, TGFB1I4, TSC22 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | TSC22D1 (HGNC:16826) |
|---|---|
| Function | Transcriptional repressor (PubMed:10488076). Acts on the C- type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta- induced transcription of COL1A2; via its interaction with TFE3 at E- boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000250|UniProtKB:P62500}. Cell membrane; Peripheral membrane protein [Isoform 2]: Cytoplasm. Nucleus Mitochondrion |
| Tissue Location | Ubiquitously expressed in adult tissues (PubMed:8651929, PubMed:26752201). Expressed in the postmitotic epithelial compartment at the top of intestinal mucosal villi (PubMed:12468551). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.
References
Jay P.,et al.Biochem. Biophys. Res. Commun. 222:821-826(1996).
Ohta S.,et al.Eur. J. Biochem. 242:460-466(1996).
Dmitrenko V.V.,et al.Cyt. Genet. 30:41-47(1996).
Yazaki M.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
Kawamata H.,et al.Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
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