UBE4A Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q14139 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 125 KDa |
Gene ID | 9354 |
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Other Names | Ubiquitin conjugation factor E4 A, 632-, UBE4A (HGNC:12499) |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | UBE4A (HGNC:12499) |
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Function | Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:E9Q735}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3 (By similarity).
References
Nagase T.,et al.DNA Res. 2:167-174(1995).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
Choudhary C.,et al.Science 325:834-840(2009).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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