AE4 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q96Q91 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 108 KDa |
Gene ID | 83697 |
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Other Names | Anion exchange protein 4, AE 4, Anion exchanger 4, Sodium bicarbonate cotransporter 5, Solute carrier family 4 member 9, SLC4A9, AE4, SBC5 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | SLC4A9 (HGNC:11035) |
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Function | Electroneutral Cl(-)/HCO3(-) antiporter that favors chloride ion entry and efflux of hydrogencarbonate and sodium ion across the basolateral membrane and may participate in salivary secretion (PubMed:27114614). Also mediates Cl(-)/HCO3(-) exchange activity in the presence of K(+) as well as Cs(+), Li(+), and Rb(+) (By similarity). Does not contribute to Cl(-)/HCO3(-) exchanger in the apical membrane of the upper villous epithelium (By similarity). |
Cellular Location | Basolateral cell membrane {ECO:0000250|UniProtKB:A0A494BA31}; Multi-pass membrane protein. Note=Localized in the basolateral membrane of the cortical collecting duct (CCD)and submandibular gland (SMG) duct {ECO:0000250|UniProtKB:A0A494BA31} |
Tissue Location | Kidney specific. {ECO:0000269|PubMed:11305939, ECO:0000269|Ref.7} |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable apical anion exchanger of the kidney cortex (By similarity).
References
Parker M.D.,et al.Biochem. Biophys. Res. Commun. 282:1103-1109(2001).
Lipovich L.,et al.Genome Biol. 2:RESEARCH0011.1-RESEARCH0011.13(2001).
Schmutz J.,et al.Nature 431:268-274(2004).
Karet F.E.,et al.Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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