ATP6 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P00846 |
Reactivity | Human, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 27 KDa |
Gene ID | 4508 |
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Other Names | ATP synthase subunit a, F-ATPase protein 6, MT-ATP6, ATP6, ATPASE6, MTATP6 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | MT-ATP6 |
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Synonyms | ATP6, ATPASE6, MTATP6 |
Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane. |
Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
References
Anderson S.,et al.Nature 290:457-465(1981).
Horai S.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995).
Ingman M.,et al.Nature 408:708-713(2000).
Maca-Meyer N.,et al.BMC Genet. 2:13-13(2001).
Silva W.A. Jr.,et al.Am. J. Hum. Genet. 71:187-192(2002).
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