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PTP kappa Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q15262 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 65 KDa |
| Gene ID | 5796 |
|---|---|
| Other Names | Receptor-type tyrosine-protein phosphatase kappa, Protein-tyrosine phosphatase kappa, R-PTP-kappa, PTPRK, PTPK |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | PTPRK |
|---|---|
| Synonyms | PTPK |
| Function | Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. |
| Cellular Location | Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein |
| Tissue Location | High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.
References
Fuchs M.,et al.J. Biol. Chem. 271:16712-16719(1996).
Yang Y.,et al.Gene 186:77-82(1997).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Tarcic G.,et al.Curr. Biol. 19:1788-1798(2009).
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