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HEXIM2 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96MH2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42 KDa |
| Gene ID | 124790 |
|---|---|
| Other Names | Protein HEXIM2, Hexamethylene bis-acetamide-inducible protein 2, HEXIM2 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | HEXIM2 |
|---|---|
| Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
References
Petroziello J.,et al.Oncogene 23:7734-7745(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Byers S.A.,et al.J. Biol. Chem. 280:16360-16367(2005).
Yik J.H.N.,et al.J. Biol. Chem. 280:16368-16376(2005).
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