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IL-5 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P05113 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 15 KDa |
| Gene ID | 3567 |
|---|---|
| Other Names | Interleukin-5, IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor, TRF, IL5 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-5. The exact sequence is proprietary. |
| Dilution | WB~~1:1000 E~~N/A |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | IL5 |
|---|---|
| Function | Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276). Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB (PubMed:1495999, PubMed:22528658). Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (PubMed:7613138). |
| Cellular Location | Secreted. |
| Tissue Location | Present in peripheral blood mononuclear cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.
References
Azuma C.,et al.Nucleic Acids Res. 14:9149-9158(1986).
Tanabe T.,et al.J. Biol. Chem. 262:16580-16584(1987).
Campbell H.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:6629-6633(1987).
Yokota T.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:7388-7392(1987).
Honjo T.,et al.Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
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