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DIAPH2 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O60879 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 130 KDa |
| Gene ID | 1730 |
|---|---|
| Other Names | Protein diaphanous homolog 2, Diaphanous-related formin-2, DRF2, DIAPH2, DIA |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | DIAPH2 |
|---|---|
| Synonyms | DIA |
| Function | Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. |
| Cellular Location | [Isoform 3]: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes |
| Tissue Location | Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
References
Bione S.,et al.Am. J. Hum. Genet. 62:533-541(1998).
Gasman S.,et al.Nat. Cell Biol. 5:195-204(2003).
Gasman S.,et al.Nat. Cell Biol. 5:680-680(2003).
Ross M.T.,et al.Nature 434:325-337(2005).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
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