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CHD3 (C-terminus) Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC, IP |
|---|---|
| Primary Accession | Q12873 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Calculated MW | 260 KDa |
| Gene ID | 1107 |
|---|---|
| Other Names | 226;2600010P09Rik;AF020312;ATP dependent helicase CHD3;ATP-dependent helicase Chd3;CHD-3;Chd3;CHD3_HUMAN;Chd7;Chromodomain-helicase-DNA-binding protein 3;hZFH;MGC40857;Mi 2 autoantigen 240 kDa protein;Mi 2a;Mi-2 autoantigen 240 kDa protein;Mi2 ALPHA;Mi2-alpha; Prp7;Prp9 1;ZFH;Zinc finger helicase;zinc-finger helicase (Snf2-like). |
| Dilution | IP~~1:500 WB~~1:1000 ICC~~1:400 |
| Format | ascites containing 0.09% (W/V) NaN3 & 50% glycerol |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CHD3 |
|---|---|
| Function | ATP-dependent helicase that binds and distorts nucleosomal DNA (PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:9804427, PubMed:30397230, PubMed:16428440, PubMed:28977666). Involved in transcriptional repression as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). |
| Cellular Location | Nucleus, PML body. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Associates with centrosomes in interphase and mitosis (PubMed:17626165). Localizes to sites of DNA damage (PubMed:28977666) |
| Tissue Location | Widely expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
References
Aubry F.,et al.Eur. J. Biochem. 254:558-564(1998).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Woodage T.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11472-11477(1997).
Ge Q.,et al.J. Clin. Invest. 96:1730-1737(1995).
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