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CHD4 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | Q14839 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Calculated MW | 260 KDa |
| Gene ID | 1108 |
|---|---|
| Other Names | ATP dependent helicase CHD4;ATP-dependent helicase CHD4;CHD 4;CHD-4;CHD4;CHD4_HUMAN; Chromodomain helicase DNA binding protein 4;Chromodomain-helicase-DNA-binding protein 4;DKFZp686E06161;Mi 2 autoantigen 218 kDa protein;Mi 2b;Mi-2 autoantigen 218 kDa protein;Mi2 beta;Mi2-beta. |
| Dilution | IP~~1:500 WB~~1:1000 |
| Format | Purified mouse monoclonal in PBS(pH 7.4)containing with 0.09% (W/V) sodium azide,50% glycerol. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CHD4 |
|---|---|
| Function | ATP-dependent helicase that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:17626165, PubMed:9804427, PubMed:16428440, PubMed:28977666). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity). |
| Cellular Location | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes in interphase (By similarity). Localizes to sites of DNA damage in a manner dependent on ZMYND8 and ZNF687 (PubMed:28977666, PubMed:27732854). {ECO:0000250|UniProtKB:Q6PDQ2, ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28977666} |
| Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.
References
Seelig H.P.,et al.Arthritis Rheum. 38:1389-1399(1995).
Scherer S.E.,et al.Nature 440:346-351(2006).
Tong J.K.,et al.Nature 395:917-921(1998).
Schmidt D.R.,et al.Biochemistry 38:14711-14717(1999).
Kim J.,et al.Immunity 10:345-355(1999).
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