EIF4EBP3 Antibody
Purified Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O60516 |
Reactivity | Transfected |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG1 |
Calculated MW | 11 KDa |
Gene ID | 8637 |
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Other Names | 4E BP3; 4E-BP3; 4EBP3; eIF4E binding protein 3; Eukaryotic initiation factor 4E binding protein 3; Eukaryotic translation initiation factor 4E binding protein 3; OTTHUMP00000159879. |
Dilution | WB~~1:1000 |
Format | Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | EIF4EBP3 |
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Function | Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:22684010). |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulates eIF4E activity by preventing its assembly into the eIF4F complex.
References
Poulin F.,et al.J. Biol. Chem. 273:14002-14007(1998).
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