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RhoG Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P84095 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21 KDa |
| Antigen Region | 97-146 aa |
| Gene ID | 391 |
|---|---|
| Other Names | Rho-related GTP-binding protein RhoG, RHOG, ARHG |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the center region of human RhoG. The exact sequence is proprietary. |
| Dilution | WB~~ 1:1000 |
| Format | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | RHOG |
|---|---|
| Synonyms | ARHG |
| Function | Plays a role in immunological synaptic F-actin density and architecture organization (PubMed:33513601). Regulates actin reorganization in lymphocytes, possibly through the modulation of Rac1 activity (PubMed:33513601). Required for the formation of membrane ruffles during macropinocytosis (PubMed:15133129). Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (PubMed:17875742). Binds phospholipids in an activation-dependent manner; thereby acting as an anchor for other proteins to the plasma membrane (PM) (PubMed:33513601). Plays a role in exocytosis of cytotoxic granules (CG) by lymphocytes/Component of the exocytosis machinery in natural killer (NK) and CD8+ T cells (PubMed:33513601). Promotes the docking of cytotoxic granules (CG) to the plasma membrane through the interaction with UNC13D (PubMed:33513601). Involved in the cytotoxic activity of lymphocytes/primary CD8+ T cells (PubMed:33513601). |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.
References
Vincent S.,et al.Mol. Cell. Biol. 12:3138-3148(1992).
Miki T.,et al.Nature 362:462-465(1993).
Puhl H.L. III,et al.Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
Ellerbroek S.M.,et al.Mol. Biol. Cell 15:3309-3319(2004).
Patel J.C.,et al.J. Cell Biol. 175:453-463(2006).
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