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CDK11B Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P21127 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 110,92 KDa |
| Antigen Region | 1-50 aa |
| Gene ID | 984 |
|---|---|
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human CDK11B. The exact sequence is proprietary. |
| Dilution | WB~~1:1000 |
| Format | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CDK11B |
|---|---|
| Synonyms | CDC2L1, CDK11, PITSLREA, PK58 |
| Function | Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity- dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Expressed ubiquitously. Some evidence of isoform- specific tissue distribution. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
References
Bunnell B.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7467-7471(1990).
Bunnell B.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:2612-2612(1991).
Eipers P.G.,et al.Genomics 13:613-621(1992).
Xiang J.,et al.J. Biol. Chem. 269:15786-15794(1994).
Gururajan R.,et al.Genome Res. 8:929-939(1998).
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