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GTF2IRD1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9UHL9 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 106 KDa |
| Antigen Region | 71-120 aa |
| Gene ID | 9569 |
|---|---|
| Dilution | WB~~ 1:1000 |
| Format | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | GTF2IRD1 |
|---|---|
| Synonyms | CREAM1, GTF3, MUSTRD1, RBAP2, WBSCR11, W |
| Function | May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow- twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity).
References
O'Mahoney J.V.,et al.Mol. Cell. Biol. 18:6641-6652(1998).
Osborne L.R.,et al.Genomics 57:279-284(1999).
Tassabehji M.,et al.Eur. J. Hum. Genet. 7:737-747(1999).
Franke Y.,et al.Cytogenet. Cell Genet. 86:296-304(1999).
Yan X.,et al.Biochem. J. 345:749-757(2000).
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