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CNOT7 Rabbit pAb
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- BACKGROUND
Application 
| WB, IHC, FC, IP |
|---|---|
| Primary Accession | Q60809 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal Antibody |
| Calculated MW | 32718 Da |
| Gene ID | 18983 |
|---|---|
| Other Names | CCR4-NOT transcription complex subunit 7, 3.1.13.4, CCR4-associated factor 1, CAF-1, Cnot7, Caf1 |
| Dilution | WB~~1:1000 IHC~~1:100~500 FC~~1:10~50 IP~~N/A |
| Name | Cnot7 |
|---|---|
| Synonyms | Caf1 |
| Function | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA- mediated mRNA deadenylation. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. |
| Cellular Location | Nucleus. Cytoplasm, P-body. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q9UIV1}. Note=NANOS2 promotes its localization to P-body (PubMed:20133598). Recruited to cytoplasmic ribonucleoprotein membraneless compartments by CAPRIN1, promoting deadenylation of mRNAs (By similarity) {ECO:0000250|UniProtKB:Q9UIV1, ECO:0000269|PubMed:20133598} |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP53529
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