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> home > Products > Primary Antibodies > Antibody Collections > mRNA transport > ENY2 Antibody (N-term)
ENY2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NPA8 |
| Other Accession | Q3KPT5, Q9JIX0, Q3ZBJ0, NP_064574.1 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 11529 Da |
| Antigen Region | 2-31 aa |
| Gene ID | 56943 |
|---|---|
| Other Names | Transcription and mRNA export factor ENY2 {ECO:0000255|HAMAP-Rule:MF_03046}, Enhancer of yellow 2 transcription factor homolog {ECO:0000255|HAMAP-Rule:MF_03046}, ENY2 {ECO:0000255|HAMAP-Rule:MF_03046} |
| Target/Specificity | This ENY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human ENY2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ENY2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ENY2 {ECO:0000255|HAMAP-Rule:MF_03046} |
|---|---|
| Function | Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor- mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820). |
| Cellular Location | Nucleus, nucleoplasm {ECO:0000255|HAMAP- Rule:MF_03046, ECO:0000269|PubMed:22307388}. Note=Localization at the nuclear pore complex requires NUP153 and TPR |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Zhao, Y., et al. Mol. Cell 29(1):92-101(2008)
Georgieva, S., et al. Mol. Cell. Biol. 21(15):5223-5231(2001)
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$ 385.00
$ 150.00
Cat# AP5379a
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