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> home > Products > Primary Antibodies > Signal Transduction > Anti-PKC iota/zeta (pT412/410) Antibody
Anti-PKC iota/zeta (pT412/410) Antibody
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Application 
| WB, IF, IH |
|---|---|
| Primary Accession | P41743 |
| Other Accession | Q05513 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 68262 Da |
| Gene ID | 5584 |
|---|---|
| Other Names | DXS1179E; Protein kinase C iota type; Atypical protein kinase C-lambda/iota; PRKC-lambda/iota; aPKC-lambda/iota; nPKC-iota; PKC2; Protein kinase C zeta type; nPKC-zeta |
| Target/Specificity | Recognizes endogenous levels of PKC iota/zeta (pT412/410) protein. |
| Dilution | WB~~1/500 - 1/1000 IH~~1/50 - 1/200 IF~~1/50 - 1/200 |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | PRKCI |
|---|---|
| Synonyms | DXS1179E |
| Function | Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). |
| Cellular Location | Cytoplasm. Membrane. Endosome Nucleus Note=Transported into the endosome through interaction with SQSTM1/p62 After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A. |
| Tissue Location | Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets Highly expressed in non-small cell lung cancers |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Rabbit polyclonal antibody to PKC iota/zeta (pT412/410)
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$ 350.00
Cat# AP53886
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