Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
PTAFR Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P25105 |
| Other Accession | NP_001158195.1, NP_000943.1, NP_001158194.1, NP_001158193.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39203 Da |
| Antigen Region | 286-312 aa |
| Gene ID | 5724 |
|---|---|
| Other Names | Platelet-activating factor receptor, PAF-R, PAFr, PTAFR, PAFR |
| Target/Specificity | This PTAFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-312 amino acids from the C-terminal region of human PTAFR. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTAFR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTAFR |
|---|---|
| Synonyms | PAFR |
| Function | Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
PTAFR shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.
References
Davila, S., et al. Genes Immun. (2010) In press :
Hirota, N., et al. J. Biol. Chem. 285(8):5931-5940(2010)
Kaneko, K., et al. J. Invest. Dermatol. 129(11):2567-2573(2009)
Melnikova, V.O., et al. J. Biol. Chem. 284(42):28845-28855(2009)
Poisson, C., et al. J. Immunol. 183(4):2747-2757(2009)
Sugimoto, T., et al. Biochem. Biophys. Res. Commun. 189(2):617-624(1992)
Seyfried, C.E., et al. Genomics 13(3):832-834(1992)
Kunz, D., et al. J. Biol. Chem. 267(13):9101-9106(1992)
Shukla, S.D. FASEB J. 6(6):2296-2301(1992)
Ye, R.D., et al. Biochem. Biophys. Res. Commun. 180(1):105-111(1991)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
