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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > GNRHR2 Polyclonal Antibody
GNRHR2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q96P88 |
| Reactivity | Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GNRHR2 |
| Epitope Specificity | 81-180/292 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the G-protein coupled receptor 1 family. |
| Post-translational modifications | Phosphorylated on the C-terminal cytoplasmic tail (Probable). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle. This hypothalamic hormone is transported to the pituitary, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Localized to the cell membrane, GnRHR2 mediates its own receptor activity via association with G proteins, thereby activating a phosphatidylinositol-calcium second messenger system that regulates GnRHR2 function. GnRHR2 is thought to have potent antiproliferative effects on ovarian and endometrial cancer cells, suggesting a possible role in tumor suppression. Due to alternative splicing events, GnRHR2 is expressed as two isoforms. |
| Other Names | Putative gonadotropin-releasing hormone II receptor, GnRH II receptor, GnRH-II-R, Type II GnRH receptor, GNRHR2 |
|---|---|
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | GNRHR2 |
|---|---|
| Function | Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed in many tissues. |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP54488
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