Manic Fringe Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IHC-F, IF, ICC |
---|---|
Primary Accession | O00587 |
Reactivity | Rat, Chimpanzee, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 36202 Da |
Gene ID | 4242 |
---|---|
Other Names | Beta-1, 3-N-acetylglucosaminyltransferase manic fringe, 2.4.1.222, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, MFNG |
Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | MFNG (HGNC:7038) |
---|---|
Function | Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (By similarity). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). |
Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
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