PNLDC1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IHC-F, IF, ICC |
---|---|
Primary Accession | Q8NA58 |
Reactivity | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 60124 Da |
Gene ID | 154197 |
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Other Names | Poly(A)-specific ribonuclease PNLDC1, 3.1.13.4, PARN-like domain-containing protein 1 {ECO:0000312|HGNC:HGNC:21185}, Poly(A)-specific ribonuclease domain-containing protein 1 {ECO:0000312|HGNC:HGNC:21185}, HsPNLDC1, PNLDC1 (HGNC:21185) |
Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | PNLDC1 (HGNC:21185) |
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Function | 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (By similarity). Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs (PubMed:34347949). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Localizes mainly in the endoplasmic reticulum (PubMed:27515512). |
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