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Genethonin 1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | O95210 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 39 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Genethonin 1 |
| Epitope Specificity | 1-100/358 |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane. Distributed in the transverse tubules and/or near the junctional sarcoplasmic reticulum. |
| SIMILARITY | Contains 1 CBM20 (carbohydrate binding type-20) domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Genethonin-1 is a 358 amino acid single-pass type III membrane protein that contains one CBM20 (carbohydrate binding type-20) domain. A hydrophobic protein, Genethonin-1 is highly expressed in cardiac and skeletal muscle and is found at moderate levels in placenta and liver. Genethonin-1 and is thought to function in carbohydrate binding. The gene encoding Genethonin-1 maps to human chromosome 4, which represents approximately 6% of the human genome, contains nearly 900 genes and is associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. |
| Gene ID | 8987 |
|---|---|
| Other Names | Starch-binding domain-containing protein 1, Genethonin-1, Glycophagy cargo receptor STBD1, STBD1 {ECO:0000303|PubMed:20810658} |
| Target/Specificity | Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level). |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | STBD1 {ECO:0000303|PubMed:20810658} |
|---|---|
| Function | Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes. |
| Cellular Location | Preautophagosomal structure membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Cell membrane, sarcolemma, T-tubule. Note=Also detected near the junctional sarcoplasmic reticulum (PubMed:9794794) Concentrates at perinuclear structures (PubMed:21893048) |
| Tissue Location | Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level). |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 385.00
Cat# AP55139
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