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GOLGA7 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q7Z5G4 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 16 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GOLGA7 |
| Epitope Specificity | 51-137/137 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Golgi apparatus membrane; Lipid-anchor |
| SIMILARITY | Belongs to the ERF4 family. |
| SUBUNIT | Interacts with GOLGA3. Interacts with ZDHHC9. |
| Post-translational modifications | Palmitoylated on Cys-69 and Cys-72; which is required for Golgi localization and interaction with GOLGA3. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | GOLGA7 is a multi-pass membrane protein belonging to the Erf4 family of proteins. It is the functional ortholog of the yeast Erf4 protein. Localizing to the Golgi apparatus, GOLGA7 is a widely expressed protein but its expression is absent from colon and thymus tissues. GOLGA7 is palmitoylated on two cysteine residues, and this palmitoylation is required for its interaction with golgin 160 and its Golgi-localization. GOLGA7 also forms a complex with ZDHHC9 and, together, these proteins function as a Ras palmitoyltransferase (Ras PAT) which is required for palmitoylation of H-Ras and N-Ras proteins. The palmitoylation of Ras proteins is essential for the trafficking of Ras proteins from the Golgi to the plasma membrane, thus implicating GOLGA7 in protein transport from the Golgi to the cell surface. |
| Gene ID | 51125 |
|---|---|
| Other Names | Golgin subfamily A member 7, Golgi complex-associated protein of 16 kDa, GOLGA7, GCP16 |
| Target/Specificity | Expressed in all tissues except colon and thymus. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | GOLGA7 |
|---|---|
| Synonyms | GCP16 |
| Function | May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS. |
| Cellular Location | Golgi apparatus membrane; Lipid- anchor |
| Tissue Location | Expressed in all tissues except colon and thymus. |
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP55177
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