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ZMYM2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q9CU65 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 160 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ZMYM2/ZNF198 |
| Epitope Specificity | 1051-1150/1377 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Contains 9 MYM-type zinc fingers. |
| DISEASE | Note=A chromosomal aberration involving ZMYM2 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with FGFR1. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF198 (zinc finger 198), also known as ZMYM2 (zinc finger, MYM-type 2), FIM, MYM, RAMP or SCLL, is a 1,377 amino acid protein that localizes to the nucleus and contains nine MYM-type zinc fingers. Thought to be a component of the BHC histone deacetylase complex, ZNF198 interacts with HDAC1 and HDAC2 and is thought to stabilize the BHC complex via its MYM-type zinc fingers. The gene encoding ZNF198 is subject to a translocation with Flg, an event that may be involved in the pathogenesis of stem cell leukemia lymphoma syndrome (SCLL), a lymphoblastic lymphoma often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. |
| Gene ID | 76007 |
|---|---|
| Other Names | Zinc finger MYM-type protein 2, Zinc finger protein 198, Zmym2, Zfp198, Znf198 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | Zmym2 |
|---|---|
| Synonyms | Zfp198, Znf198 |
| Function | Involved in the negative regulation of transcription. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9UBW7}. |
| Tissue Location | Low but widespread expression is detected in the developing kidney. |
Research Areas
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$ 385.00
Cat# AP55217
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