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CCK39 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | P06307 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 11 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human CCK39 |
| Epitope Specificity | 51-115/115 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Secreted. |
| SIMILARITY | Belongs to the gastrin/cholecystokinin family. |
| SUBUNIT | Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain. |
| Post-translational modifications | The precursor is cleaved by proteases to produce a number of active cholecystokinins. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]. |
| Gene ID | 885 |
|---|---|
| Other Names | Cholecystokinin, CCK, Cholecystokinin-58, CCK58, Cholecystokinin-58 desnonopeptide, (1-49)-CCK58, Cholecystokinin-39, CCK39, Cholecystokinin-33, CCK33, Cholecystokinin-25, CCK25, Cholecystokinin-18, CCK18, Cholecystokinin-12, CCK12, Cholecystokinin-8, CCK8, Cholecystokinin-7, CCK7, Cholecystokinin-5, CCK5, CCK |
| Target/Specificity | The shortest form (CCK8) is predominantly found in the brain, whereas the larger ones are found in the intestine. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | CCK |
|---|---|
| Function | This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. |
| Cellular Location | Secreted |
| Tissue Location | Detected in cerebrospinal fluid and urine (at protein level). |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 385.00
Cat# AP55343
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