BLOC1S2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
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Primary Accession | Q6QNY1 |
Other Accession | Q4R7C8, NP_776170.2 |
Reactivity | Human, Mouse |
Predicted | Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 15961 Da |
Antigen Region | 14-40 aa |
Gene ID | 282991 |
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Other Names | Biogenesis of lysosome-related organelles complex 1 subunit 2, BLOC-1 subunit 2, Centrosome-associated protein, BLOC1S2, BLOS2, CEAP |
Target/Specificity | This BLOC1S2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-40 amino acids from the Central region of human BLOC1S2. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | BLOC1S2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BLOC1S2 |
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Synonyms | BLOS2, CEAP |
Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421). |
Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Lysosome membrane. Note=Localizes to the centrosomes in a microtubule-dependent manner. |
Tissue Location | Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
BLOC1S2 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]).
References
Rodriguez-Fernandez, I.A., et al. J. Inherit. Metab. Dis. 32(2):190-203(2009)
Gdynia, G., et al. Apoptosis 13(3):437-447(2008)
Wang, Z., et al. J. Mol. Biol. 343(1):71-82(2004)
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