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DHX37 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q8IY37 |
| Reactivity | Rat, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 129545 Da |
| Gene ID | 57647 |
|---|---|
| Other Names | Probable ATP-dependent RNA helicase DHX37, 3.6.4.13, DEAH box protein 37, DHX37, DDX37, KIAA1517 |
| Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | DHX37 (HGNC:17210) |
|---|---|
| Synonyms | DDX37, KIAA1517 |
| Function | ATP-binding RNA helicase that plays a role in maturation of the small ribosomal subunit in ribosome biogenesis (PubMed:30582406). Required for the release of the U3 snoRNP from pre-ribosomal particles (PubMed:30582406). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Plays a role in early testis development (PubMed:31287541, PubMed:31337883). Probably also plays a role in brain development (PubMed:31256877). |
| Cellular Location | Nucleus, nucleolus. Cytoplasm. Nucleus membrane |
| Tissue Location | Expressed in the fallopian tube, ovary, uterus and testis. Also expressed in the brain. |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP55523
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