ESCO2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F, IF, ICC |
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Primary Accession | Q56NI9 |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 68307 Da |
Gene ID | 157570 |
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Other Names | N-acetyltransferase ESCO2, 2.3.1.-, Establishment factor-like protein 2, EFO2, EFO2p, hEFO2, Establishment of cohesion 1 homolog 2, ECO1 homolog 2, ESCO2 |
Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | ESCO2 (HGNC:27230) |
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Function | Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). |
Cellular Location | Nucleus. Chromosome. Note=Nuclear in interphase cells, excluded from chromosomes during metaphase but reassociates with chromosomes in telophase. |
Tissue Location | Widely expressed in fetal tissues. In adult, it is expressed in thymus, placenta and small intestine |
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