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EXD2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q9NVH0 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 70353 Da |
| Gene ID | 55218 |
|---|---|
| Other Names | Exonuclease 3'-5' domain-containing protein 2, 3.1.11.1, 3'-5' exoribonuclease EXD2, 3.1.13.-, Exonuclease 3'-5' domain-like-containing protein 2, EXD2 {ECO:0000303|PubMed:26807646, ECO:0000312|HGNC:HGNC:20217} |
| Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | EXD2 {ECO:0000303|PubMed:26807646, ECO:0000312|HGNC:HGNC:20217} |
|---|---|
| Function | Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'- 5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466). |
| Cellular Location | Mitochondrion outer membrane; Single-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:31127291} Mitochondrion matrix. Nucleus. Chromosome. Note=Mainly localizes to the mitochondrial outer membrane (PubMed:29599527, PubMed:31127291). May translocate to the nucleus in response to DNA damage; however mechanism that explain nuclear localization are unknown and require experimental evidences (PubMed:26807646). Recruited to replication forks following replication stress (PubMed:31255466). |
Citations (0)
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Application Protocols
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$ 350.00
Cat# AP55658
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