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FAM122A Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q96E09 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 30529 Da |
| Gene ID | 116224 |
|---|---|
| Other Names | PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 {ECO:0000303|PubMed:33108758, ECO:0000312|HGNC:HGNC:23490}, PABIR family member 1, PABIR1 {ECO:0000303|PubMed:33108758, ECO:0000312|HGNC:HGNC:23490} |
| Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | PABIR1 {ECO:0000303|PubMed:33108758, ECO:0000312|HGNC:HGNC:23490} |
|---|---|
| Function | Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin- mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). |
| Cellular Location | Nucleus. Cytoplasm. Note=The CHEK1-mediated Ser-37 phosphorylated form is sequestered by 14-3-3 proteins in the cytoplasm and fails to translocate to the nucleus, where it otherwise inhibits serine/threonine-protein phosphatase 2A. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP55681
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