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C9orf89 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q96LW7 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 26 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human C9orf89 |
| Epitope Specificity | 1-100/228 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. Note=Co-expression with BCL10 induced translocation from nucleus to cytosol. |
| SIMILARITY | Contains 1 CARD domain. |
| SUBUNIT | Associates with BCL10 by CARD-CARD interaction. |
| Post-translational modifications | Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | C9orf89 plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. It may inhibit the phosphorylation of BCL10 in a CARD-dependent manner. There are two isoforms. |
| Gene ID | 84270 |
|---|---|
| Other Names | Caspase recruitment domain-containing protein 19, Bcl10-interacting CARD protein, BinCARD, CARD19, C9orf89 |
| Target/Specificity | Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | CARD19 |
|---|---|
| Synonyms | C9orf89 |
| Function | Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. |
| Cellular Location | [Isoform 1]: Nucleus. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol |
| Tissue Location | Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain. |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP55959
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