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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > GPCR MRGX2 Polyclonal Antibody
GPCR MRGX2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q96LB1 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 37 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GPCR MRGX2 |
| Epitope Specificity | 1-100/330 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the G-protein coupled receptor 1 family. Mas subfamily. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Mas-related G protein-coupled receptor member X1 (MRGX) is a sensory neuron-specific G protein-coupled receptor that is involved in the development and function of nociceptive neurons and may also regulate the sensation or modulation of pain. MRGPRX2, is a 330 amino acid multi-pass membrane protein that functions as an orphan receptor and, like MRGX, is thought to be involved in the function of nociceptive neurons. Expressed in the central nervous system with highest expression in dorsal root ganglia, MRGX2 may also be involved in cortistatin function, possibly playing a role in sleep regulation and cortical function. |
| Gene ID | 117194 |
|---|---|
| Other Names | Mas-related G-protein coupled receptor member X2, MRGPRX2, MRGX2 |
| Target/Specificity | Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | MRGPRX2 |
|---|---|
| Synonyms | MRGX2 |
| Function | Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Mainly expressed in mast cells. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion (PubMed:12915402) Detected in blood vessels, scattered lymphocytes, and gastrointestinal ganglia (at protein level) (PubMed:16161007) |
Research Areas
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$ 385.00
Cat# AP55967
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