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IFFO Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q0D2I5 |
| Reactivity | Rat, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61979 Da |
| Gene ID | 25900 |
|---|---|
| Other Names | Non-homologous end joining factor IFFO1, NHEJ factor IFFO1, Intermediate filament family orphan 1, Tumor antigen HOM-TES-103, IFFO1 (HGNC:24970), IFFO |
| Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | IFFO1 (HGNC:24970) |
|---|---|
| Synonyms | IFFO |
| Function | Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). |
| Cellular Location | Nucleus. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus matrix. Note=Mainly soluble, the remaining is localized in the nuclear matrix (PubMed:31548606). Localized at double- strand break (DSB) sites near the lamina and nuclear matrix structures (PubMed:31548606). |
| Tissue Location | Ubiquitously expressed. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP56035
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