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LRIT3 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q3SXY7 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 74754 Da |
| Gene ID | 345193 |
|---|---|
| Other Names | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3, LRIT3 |
| Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | LRIT3 |
|---|---|
| Function | Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (By similarity). Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina (PubMed:28334377). Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (By similarity). Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (By similarity). May also have a role in cone synapse formation (By similarity). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (PubMed:22673519). Could be a regulator of the FGFRs (PubMed:22673519). |
| Cellular Location | Cell projection, dendrite. Perikaryon {ECO:0000250|UniProtKB:W8DXL4}. Endoplasmic reticulum membrane; Single-pass type I membrane protein Note=Punctate expression at dendrite tips |
| Tissue Location | Detected in the outer plexiform layer (OPL) of the retina where it localizes to ON-bipolar cells (at protein level) |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP56145
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