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GLCE Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | O94923 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 70 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GLCE |
| Epitope Specificity | 541-617/617 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Golgi apparatus membrane; Single-pass type II membrane protein |
| SIMILARITY | Belongs to the D-glucuronyl C5-epimerase family. |
| SUBUNIT | Interacts with HS2ST1 (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | GLCE (glucuronic acid epimerase), also known as HSEPI (heparin/heparan sulfate:glucuronic acid C5-epimerase) or D-glucuronyl C5-epimerase, is a single-pass type II membrane protein that is part of the golgi apparatus and, through its enzymatic activity, is essential for proper biological function of heparan sulphate (HS). GLCE epimerizes D-glucuronic acid into L-iduronic acid of HS, thus changing the specificity of HS and allowing it to bind to cytokines and growth factors. GLCE is a target of the beta-catenin–TCF4 transactivation complex; an essential component in the Wnt/APC/beta-catenin signaling pathway that is upregulated in colon carcinoma cells. The enzymatic activity of GLCE is enhanced by overexpression of beta-catenin–TCF4, suggesting a possible role for GLCE in the dysregulation of proper signaling pathways; a dysregulation that leads to the development of human epithelial tumors. |
| Gene ID | 26035 |
|---|---|
| Other Names | D-glucuronyl C5-epimerase, 5.1.3.17, Heparan sulfate C5-epimerase, Hsepi, Heparin/heparan sulfate:glucuronic acid C5-epimerase, Heparosan-N-sulfate-glucuronate 5-epimerase, GLCE, KIAA0836 {ECO:0000312|EMBL:BAA74859.1} |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | GLCE |
|---|---|
| Synonyms | KIAA0836 {ECO:0000312|EMBL:BAA74859.1} |
| Function | Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EPS3}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9EPS3} |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP56192
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