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TRHDE Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, E |
|---|---|
| Primary Accession | Q9UKU6 |
| Other Accession | Q10836, Q8K093, NP_037513.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 122133 Da |
| Antigen Region | 951-980 aa |
| Gene ID | 29953 |
|---|---|
| Other Names | Thyrotropin-releasing hormone-degrading ectoenzyme, TRH-DE, TRH-degrading ectoenzyme, Pyroglutamyl-peptidase II, PAP-II, TRH-specific aminopeptidase, Thyroliberinase, TRHDE |
| Target/Specificity | This TRHDE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 951-980 amino acids from the C-terminal region of human TRHDE. |
| Dilution | WB~~1:1000 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRHDE Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRHDE |
|---|---|
| Function | Specific inactivation of TRH after its release. |
| Cellular Location | Membrane; Single-pass type II membrane protein. |
| Tissue Location | Predominantly expressed in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the peptidase M1 family. TRHDE is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.
References
Cirulli, E.T., et al. Eur. J. Hum. Genet. (2010) In press :
Murabito, J.M., et al. BMC Med. Genet. 8 SUPPL 1, S6 (2007) :
Schomburg, L., et al. Eur. J. Biochem. 265(1):415-422(1999)
Bodeker, H., et al. Mol. Cell Biol. Res. Commun. 2(3):150-154(1999)
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