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IRF2BPL Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q9H1B7 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 82659 Da |
| Gene ID | 64207 |
|---|---|
| Other Names | Probable E3 ubiquitin-protein ligase IRF2BPL, 2.3.2.27, Enhanced at puberty protein 1, Interferon regulatory factor 2-binding protein-like, IRF2BPL, C14orf4, EAP1, KIAA1865 |
| Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | IRF2BPL |
|---|---|
| Synonyms | C14orf4, EAP1, KIAA1865 |
| Function | Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q5EIC4}. |
| Tissue Location | Highly expressed in the heart, moderately in skeletal muscle and pancreas, and weakly in brain, kidney, liver, testis, thyroid gland and lymphocytes. |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP56363
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