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TRF41 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q5XG87 |
| Reactivity | Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TRF41 |
| Epitope Specificity | 701-772/772 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm {ECO:0000269|PubMed:23376078}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23376078}. Note=Excluded from nucleolus, weak staining detected in the cytoplasm. |
| SIMILARITY | Belongs to the DNA polymerase type-B-like family. Contains 1 PAP-associated domain. |
| SUBUNIT | Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010] |
| Gene ID | 11044 |
|---|---|
| Other Names | Terminal nucleotidyltransferase 4A, DNA polymerase sigma, LAK-1, Non-canonical poly(A) RNA polymerase PAPD7, 2.7.7.19, PAP-associated domain-containing protein 7, TRAMP-like complex polyadenylate polymerase, Terminal guanylyltransferase, 2.7.7.-, Terminal uridylyltransferase 5, TUTase 5, Topoisomerase-related function protein 4-1, TRF4-1, TENT4A (HGNC:16705) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | TENT4A (HGNC:16705) |
|---|---|
| Function | Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication- dependent histone mRNA degradation via uridylation (PubMed:23376078). |
| Cellular Location | Cytoplasm. Nucleus, nucleoplasm. Note=Excluded from nucleolus, weak staining detected in the cytoplasm |
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP56371
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