TRIM45 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P, IHC-F, IF, ICC, E |
---|---|
Primary Accession | Q9H8W5 |
Reactivity | Rat, Pig, Dog, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 64 KDa |
Physical State | Liquid |
Immunogen | KLH conjugated synthetic peptide derived from human TRIM45 |
Epitope Specificity | 101-200/580 |
Isotype | IgG |
Purity | affinity purified by Protein A |
Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
SUBCELLULAR LOCATION | Cytoplasm. Nucleus. |
SIMILARITY | Belongs to the TRIM/RBCC family. Contains 2 B box-type zinc fingers. Contains 1 filamin repeat. Contains 1 RING-type zinc finger. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
Background Descriptions | This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009] |
Gene ID | 80263 |
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Other Names | Tripartite motif-containing protein 45, RING finger protein 99, TRIM45, RNF99 |
Target/Specificity | Expressed in skeletal muscle, brain, heart and pancreas. |
Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | TRIM45 |
---|---|
Synonyms | RNF99 |
Function | E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779). Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response (PubMed:36681779). May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Expressed in skeletal muscle, brain, heart and pancreas. |

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