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KAT6B Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q8WYB5 |
| Reactivity | Rat, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 230 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KAT6B |
| Epitope Specificity | 1151-1250/2073 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Belongs to the MYST (SAS/MOZ) family. Contains 1 C2HC-type zinc finger. Contains 1 H15 (linker histone H1/H5 globular) domain. Contains 2 PHD-type zinc fingers. |
| Post-translational modifications | Autoacetylated. |
| DISEASE | Note=A chromosomal aberration involving MYST4 may be a cause acute myeloid leukemias. Translocation t(10;16)(q22;p13) with CREBBP. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] |
| Gene ID | 23522 |
|---|---|
| Other Names | Histone acetyltransferase KAT6B, 2.3.1.48, Histone acetyltransferase MOZ2, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4, MYST-4, Monocytic leukemia zinc finger protein-related factor, KAT6B, KIAA0383, MORF, MOZ2, MYST4 |
| Target/Specificity | Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | KAT6B |
|---|---|
| Synonyms | KIAA0383, MORF, MOZ2, MYST4 |
| Function | Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2- dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed, with high levels in heart, pancreas, testis and ovary. |
Citations (0)
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$ 385.00
Cat# AP56547
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