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LAX1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q8IWV1 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 44 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human LAX1 |
| Epitope Specificity | 15-120/398 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell Membrane; Single-pass type III membrane protein. |
| SUBUNIT | When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2. |
| Post-translational modifications | Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation; which leads to the recruitment of GRB2, PIK3R1 and GRAP2. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | LAX1 is a 398 amino acid single-pass type III membrane protein that negatively regulates lymphocyte signaling. LAX1 is expressed in lymphoid tissues including thymus, spleen and peripheral blood leukocytes, along with several B-cell, T-cell, natural killer and monocyte cell lines. When stimulated by B or T cells, LAX1 becomes dramatically upregulated and also interacts with GRB2, Gads and PI 3-kinase p85 upon phosphorylation. LAX1 exists as two alternatively spliced isoforms that are encoded by a gene located on human chromosome 1. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. |
| Gene ID | 54900 |
|---|---|
| Other Names | Lymphocyte transmembrane adapter 1, Linker for activation of X cells, Membrane-associated adapter protein LAX, LAX1, LAX |
| Target/Specificity | Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | LAX1 |
|---|---|
| Synonyms | LAX |
| Function | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. |
| Cellular Location | Cell membrane; Single-pass type III membrane protein |
| Tissue Location | Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP56562
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