IYD Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IHC-F, IF, ICC |
---|---|
Primary Accession | Q6PHW0 |
Reactivity | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 33360 Da |
Gene ID | 389434 |
---|---|
Other Names | Iodotyrosine deiodinase 1, IYD-1, 1.21.1.1, Iodotyrosine dehalogenase 1 {ECO:0000303|PubMed:15289438, ECO:0000303|Ref.2}, IYD {ECO:0000303|PubMed:25395621} |
Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | IYD {ECO:0000303|PubMed:25395621} |
---|---|
Function | Catalyzes the dehalogenation of halotyrosines such as 3- bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5- diiodo-L-tyrosine (PubMed:15289438, PubMed:18434651, PubMed:25395621, PubMed:28157283). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:18434651). The scavanged iodide can then reenter the hormone- producing pathways (PubMed:15289438, PubMed:18434651). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (PubMed:15289438). |
Cellular Location | Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane |
Tissue Location | Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea. |
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